Yes, I have had success using SpyderPrint. I'm on Windows 7 x64, PS, Epson R3000, but I see no reason you should have problems on your Mac system. The SpyderPrint profiles are excellent, but not hugely different from the Epson profiles that came with the R3000. With a properly calibrated monitor, either SpyderPrint or Epson profiles should give you very good results.
Are you calibrating and profiling your monitor with Spyder4 or another similar, hardware calibrating device? That's the first step.
John